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Na´ve Substitution

Selenium and Cancer Prevention

As scientists and health professionals continue to collectively re-think the role of selenium and other nutrients in cancer prevention, investigators must work to carefully document the form-dependent effects of nutrients. By avoiding a mindset of na´ve substitution — seeing one form of nutrient as equivalent to another — we make surer progress toward understanding the implications of our laboratory findings and side-stepping errant assumptions. Moreover, this disciplined approach might help us to avoid potential pitfalls in the design and interpretation of large-scale human trials.

  • Read our manuscript that introduces the term "na´ve substitution" to the scientific literature

  • More Na´ve Substitutions