Gerald P Murphy masthead

As scientists and health professionals continue to collectively re-think the role of selenium and other nutrients in cancer prevention,
investigators must work to carefully document the form-dependent effects of nutrients. By avoiding a mindset of na´ve substitution —
seeing one form of nutrient as equivalent to another
— we make surer progress toward understanding the implications of our laboratory
findings and side-stepping errant assumptions. Moreover, this disciplined approach might help us to avoid potential pitfalls in the design
and interpretation of large-scale human trials.